The ancient civilization vanished ages ago, and a few of its remnants still exist as myths and legends called UMAs (unidentified lifeforms). The UMAs begin merging with humans in order to search for the treasures of Mu, the powerful ooparts, which will give them the power to revive Mu. After Geo and Omega-Xis encounter several unusual enemies, they meet a professor named Doctor Orihime who sends them on a quest to find the ooparts and stop the UMAs. Using the ooparts, Mega Man is able to take new forms, including Thunder Berserk, Fire Dinosaur, and Green Shinobi. The series premiered November 3, immediately after the original series's conclusion.

Years ago, Mu , an ancient civilization had vanished. But there were three treasures left behind by the land of Mu, these treasures were called OOParts (Out Of Place Artifacts) bearing the power to give Rockman the forms of "Thunder Berserker", "Green Shinobi", and "Fire Dinasor". It starts with Subaru at a museum finding the first artifact "The Sword of Berserk" releasing an enormous amount of Em Waves. Just after two Denpa Lifeforms attack the museum to take the "Sword of Berserk". War-Rock, unexpectedly, accidentally eats it. Doctor Orihime reveals the information of the OOParts to Subaru, while revealing the names of the Denpa Lifeforms, Yeti Blizzard, Phantom Black, and Burai. In secret Doctor Orihime is a decendent of Mu. Now Rockman, and Harp Note have to face new enemies with new powers.

Source: ANN

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Prequel: Ryuusei no Rockman
Alternative setting: Irregular Hunter X