In the 22nd century, Reploids became commonplace after Dr. Cain rediscovered Dr. Light's old lab and based several designs off of Dr. Light's original, called Megaman X. X, meanwhile, has joined the Maverick Hunters, and works with unit leader Zero under the command of General Sigma. It is their job to terminate rogue Reploids, those who have become violent.

Source: ANN

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Alternative setting: Rockman.EXE
Alternative setting: Rockman.EXE Axess
Same setting: Rockman: Hoshi ni Negai o
Alternative setting: Rockman.EXE Stream
Alternative setting: Gekijouban Rockman.EXE: Hikari to Yami no Program
Alternative setting: Rockman.EXE Beast
Alternative setting: Rockman.EXE Beast+
Alternative setting: Ryuusei no Rockman
Alternative setting: Ryuusei no Rockman Tribe