In a city somewhere in Japan, there's a flyer often seen on Third Street with a picture of a cat with a kinked tail, bearing the words: "Have you seen Tama?" A young boy gazes at the flyer, but he has fluffy ears on his head...!?
Watch the dogs and cats from Third Street take on a human form and get up to some mischief. Take a peek into the wonderful lives of Tama and his friends.

Source: Official website

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Alternative setting: Tama & Friends: Uchi no Tama Shirimasenka?