Momomiya Ichigo is just an ordinary 13-year-old girl until a bizarre incident occurs at a museum during her first date. The accident, which merges her DNA with that of a wildcat's, is actually part of the µ Project to protect the Earth from danger.

Momomiya Ichigo, code name Mew Ichigo (Strawberry), along with four other chosen girls: Mew Mint (Aizawa Mint), Mew Lettuce (Midorikawa Lettuce), Mew Pudding (Fong Pudding) and Mew Zakuro (Fujiwara Zakuro) now have to protect the Earth and learn about their mysterious enemy using the Cafe Mew Mew as their base of operations.

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Alternative version: Tokyo Mew Mew New