With Earth becoming increasingly overpopulated, an ambitious plan has been put into place to terraform Mars using mold and cockroaches. Nearly 500 years after the plan, a mission to Mars, Annex 1, is under way to accomplish crucial research into the Virus currently plaguing mankind with the crew members who've been injected with various DNA of life on Earth in order to combat the Terraformars, giant humanoid cockroaches.

Source: crunchyroll

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Prequel: Terra Formars
Sequel: Terra Formars: Revenge OAD