A satanic program is activated aboard a crowded commercial flight headed for Tokyo. It releases a swarm of invisible demons that send the aircraft plunging to a fiery doom. Everyone aboard is killed instantly, except Kobayashi Akito, owner of the devilish program and a sworn ally of hell itself.

Souma Kojirou, an old elementary school friend of Akito's, is surprised to see him enroll back in school. Kojirou notices how this once lonely boy has grown into a suave and arrogant teenager. Later, when his classmates are attacked and legendary demons return to stalk to streets of Tokyo, Kojirou begins to truly understand what his old friend has become.

Akito has plans for the human race. The plans revolve around magnetite, the mysterious element that forms the living essence of every human soul. Combined with his demonic software, a strong enough source of magnetite would release a plague of devils upon the Earth. That source exists in Kojirou's class, but when the evil plan expands beyond even Akito's grasp, it is Kojiro who must find the ultimate power within himself, and go head-to-head with the greatest demon of all!

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Other: Shin Megami Tensei: Devil Children
Alternative setting: Digital Devil Story: Megami Tensei