Sawaki Souemon Tadayasu was born with an unique ability: he can see and communicate with bacteria and other micro-organisms - in fact they consider him to be their friend and are quite noisy. Together with his childhood friend Yuuki Kei, he starts a new year off as a first-year student at an Agricultural College. But none of his experiences so far could prepare him for what he would find in his college life!

Note: As this is an "educational" anime series, the last 90 seconds of each episode are devoted to a "microbe theatre" which features various micro-organisms explaining who they are and what they do.

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Sequel: Moyashimon Returns