A hundred years in the future, no one drives cars — instead, computer-controlled, electrically powered AI cars automatically take you where you want to go. However, when the AI cars mysteriously start to run amok, an organization called eX-Driver is established to figure out why.

Although no one in this world knows how to drive, there are some people, who seem to have an instinctive ability to drive old-fashioned, gasoline-powered cars, thus earning an eX licence. Two friends — Lisa, a straightforward and cheerful girl, and Lorna, a calm and easygoing type — already keep the roads safe as professional eX-Drivers.

Source: AnimeNfo

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Sequel: eX-Driver the Movie
Prequel: eX-Driver: Nina & Rei Danger Zone