Matsuda Takato, Li JianLiang, and Makino Ruki are children who have, by fate, recieved real Digimon; unlike the imaginary ones in the card game they play. Each of the children, or "Digimon Tamers", have their different views on how Digimon should be treated. But when other Digimon begin to appear around Japan, they must put aside their differences to fend off the digital intruders; even though Yamaki, who is the head of a secret organization called Hypnos is trying to eliminate all of the Digimon himself.

Source: ANN

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Same setting: Digimon Adventure
Side story: Digimon Tamers: Boukensha-tachi no Tatakai