"It is the 22nd year of the new Holy Era. With the fall of the previous age brought about by human folly, lawlessness runs rampant and disorder rules the world. But here in Shinjuku, the City of the Beasts, any creature who would harm another must contend with us, one and all. Our wild blood runs hot tonight! Hyper Police to the rescue!" — from intro

In these post-apocalyptic times beast creatures from lore have reappeared and now try to interact with normal humans. The police force has grudgingly accepted help from privatized bounty hunters, and various police businesses fight over the rewards for capturing wanted criminals. Few humans like the beast creatures, and they rarely interact.

The Police Company is one such private business, where the 17-year-old half-human / half-nekomata Sasahara Natsuki, and her tough werewolf partner Batanen try to make ends meet on a daily basis. Their boss prides himself in employing many beast creatures as officers in his force, such as Sakura, a 191-year-old fox spirit, and another werewolf named Tommy.

Needless to say, the other police forces do not like the extra competition. This is especially true for the MAD Police — the regular police in Shinjuku — comprised entirely of humans.

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