Natsume has been busy, navigating between humans and Yokai when he coincidentally reunites with an old classmate, Yuki. The reunion brings back painful memories of a certain Yokai. Meanwhile, Natsume also becomes acquainted with Tsumura Yorie, a woman in the memories of a Yokai whose name Natsume had returned. Yorie knows much about Reiko, and now lives a peaceful life with her only son, Mukuo. Interacting with this family is comforting for Natsume, but a mysterious Yokai has been lurking in their town.

On the way back from investigating, a "Yokai seed" that had latched itself to Nyanko-Sensei drops into the Fujiwara Family's garden and grows overnight into a fruit tree. When Nyanko-Sensei eats a fruit that is somewhat shaped like himself, he suddenly splits into three!

Source: Aniplex USA

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Prequel: Natsume Yuujinchou Roku
Other: Natsume Yuujinchou: Ishi Okoshi to Ayashiki Raihousha
Sequel: Natsume Yuujinchou Shichi